Anti-Claudin 1 antibodies are used for the immunodetection of the protein encoded by the CLDN1 gene. In humans, the canonical protein has a reported length of 211 amino acid residues and a mass of 22.7 kDa. Its subcellular localization is in the cell membrane. It is reported to be highly expressed in the liver and kidney. A member of the Claudin protein family, it is known to be involved with pathways of aging and cell adhesion. The claudin 1 marker can be used to characterize Type 3 Descending Thin Limb Cells.* Other names for this target antigen include ILVASC, SEMP1, senescence-associated epithelial membrane protein 1, and CLD1. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 990 citations in the literature describe the use of Claudin 1 antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4